Continuous granulation offers a more efficient and cost-effective route for producing tablets and capsules, particularly when developing new formulations where scale-up is difficult due to the narrow optimal working points found in batch devices such as mixers, agitators and choppers.
2-in-1 process design – quickly disassemble parts for easy cleaning and process switching from HME to TSG.
Simple continuous process integration – plug-and-play functionality with upstream and downstream process equipment (e.g., feeders, chill rolls, pelletizers, dryers, etc) simplifies production line design.
Less optimization time, cost and effort – extruder process parameters are scaleable to larger Thermo Scientific extruders due to geometric similarity with minimal use of expensive ingredients.
Pharmaceutical manufacturers are using conical and twin-screw extruders to mix drug molecules with bioactive polymers in situations where drug ingredients are poorly soluble or unstable during processing. Extruders are also useful in preparing enteric dosages, sustained release dosages, in taste-masking, and to create forms such as films.