Technologies

• Co- and counter-rotating twin screws
• Integrated viscosity measurement (with HAAKE PolySoft OS)
• Automatic bypass operation for circulation/extrusion
• Pneumatic feeding
• Local control via tablet (Android®) for  intuitive operation
• Split barrel exit for easy cleaning
• Compact enough to fit into laboratory fume hood’

• Minimized sample material usage (20 g)
• Throughput range 20g/h to 2.5kg/h
• Small footprint bench top design that is easily transportable
• Segmented screw design with removable top half barrel
• Easy-to-operate touch screen with integrated feeder control
• Geometrically scalable screw and barrel design across portfolio

• Throughput range 0.4 kg/h to 20 kg/h (material dependent)
• Segmented screw design and removable top half barrel
• A screw length adjustment kit enables small quantity compounding
• A fully ported barrel allows maximum flexibility for feeding and degassing
• Contact parts selectable from three steel grades
• An easy-to-operate touch screen with integrated feeder control
• Broad accessory portfolio, e.g.. dies, feeders, water bath, conveyor belt, strand or die face pelletizers, haul off, and spooler
• The granulation kit enables customers to switch between melt extrusion and wet/melt granulation
• Geometrically scalable screw and barrel design across portfolio

• Horizontally split barrel (up to 40:1 L/D) is hinged for easy access to the screws; simple screw removal device promotes quick and easy cleaning and configuration changes
• Barrel is constructed in segmented modules that can be reconfigured to suit a variety of polymer processes
• Replaceable barrel liners can be made from special materials for abrasive or aggressive applications
• Barrel segments are available for feeding solids and liquids or for venting
• Secondary feeders and vacuum pumps can also be incorporated into the system
• Powerful control software is programmed to recognize plug-in ancillaries
• Large color touch screen interface incorporates on-screen, real-time trend display

• Uses smaller material quantities for faster, cost-effective development
• Converts easily from hot melt extrusion (HME) to twin screw granulation (TSG) applications
• Operates at throughput ranges from 20g/h up to 2.5kg/h
• Processing length: L/D ratio 40:1
• Screw elements and barrel design scale geometrically across the all Thermo Scientific Pharma Extruders and allow easy process scale-up
• Easy-to-operate with user-friendly, intuitive touch screen with integrated feeder control
• Maximize lab space with small footprint machine
• Perfect for glove box or isolator applications with removable touch screen
• All material contact parts are easily removable
• Documentation of extrusion parameters and suitable for process analytical technology (PAT)
• GMP-compliant, full validation available: FAT, SAT, IQ/OQ

• 2-in-1 process design – quickly disassemble parts for easy cleaning and process switching from HME to TSG.
• Simple continuous process integration – plug-and-play functionality with upstream and downstream process equipment (e.g., feeders, chill rolls, pelletizers, dryers, etc) simplifies production line design.
• Less optimization time, cost and effort – extruder process parameters are scaleable to larger Thermo Scientific extruders due to geometric similarity with minimal use of expensive ingredients.

The HAAKE PolyLab QC Modular Torque Rheometer Features:
Backward Compatibility

• Compatible with previous model mixers and extruders
• Adapts to existing accessories for use
• Imports previous data for compatibility

• Extrudability of newly developed materials
• Manufacturing homogeneous melts
• Manufacturing films, foils, strands and profiles for optical and mechanical testing as well as outdoor exposure tests
• Measuring rheological behavior (viscosity, elasticity)
• Testing individual and combined influences of additives (stabilizer, lubricant) and functional additives (anti-oxidation, UV-stabilizers, pigments and fillers)
• Foam extrusion

Overcome drug formulation challenges

Pharmaceutical manufacturers are using conical and twin-screw extruders to mix drug molecules with bioactive polymers in situations where drug ingredients are poorly soluble or unstable during processing. Extruders are also useful in preparing enteric dosages, sustained release dosages, in taste-masking, and to create forms such as films.

Gain the advantages of a continuous process

Continuous granulation offers a more efficient and cost-effective route for producing tablets and capsules, particularly when developing new formulations where scale-up is difficult due to the narrow optimal working points found in batch devices such as mixers, agitators and choppers.

• Requires only 3g (4mL) of material for compounding
• Small footprint, fanless design with separate, touch-screen control for operation in fume cabinet or glovebox applications
• Removable and exchangeable product contact parts for quick and easy cleaning
• IP 54 for protection against dust and water allows the Pharma mini HME to be spray-washed
• Useable as small-scale production unit for throughputs of 100g/h
• Touch screen control with user levels and password protection
• Data logging software as option to record temperatures, torque, and screw speed
• Optional batch conversion kit to use the Pharma mini HME as small batch mixer
• Complementary workflow solution when coupled with the Thermo Scientific™ HAAKE™ MiniJet injection molder

• Falling ball tube with holder
• Set of 6 balls (No 1-6)
• Instrument Case
• Thermometer -1 °C bis +26 °C in 0,1 °C steps
• Cleaning tools, calibration sheet, instruction manual

• Smart alignment given by design and visualized by an electronic level
• Quick coupling of measuring geometries for fast and easy adaptation
• Color coded geometries and a geometry range indicator ensure correct rotor selection every time
• Adaptable display brightness ensures ideal readability in any environment
• Battery and power supply options allow the viscometer to be run anywhere
• Memory assist functionality allows you to quickly and easily compare measured viscosities with the reference point
• Selectable viscosity units (mPa s or dPa s)
• Compatibility with previous viscometer models

• Easy exchange between different measuring configurations for fast setup and operation
• Comprehensive portfolio of measuring geometries and accessories to tailor your instrument
• Smart lift function for convenient, accurate and reproducible gap setting
• Correct and precise sample filling for parallel plates for ultimate measuring accuracy
• Breakthrough concept self-explaining in setup and handling for error-proof operation
• Convenient touch screen display for visualization of numerical and graphical measurement results
• “Temperature Assist” rapid real sample temperature control based on a dynamic heat transfer model
• “Connect Assist” quick coupling of measuring geometries and temperature modules with perfect alignment, automatic recognition and feedback for measuring optimization
• Highly dynamic, powerful EC motor for flexibility across a range of materials and measurements

The Thermo Scientific^TM HAAKETM MARS^TM iQ Rheometer Series provides extensive flexibility and ease-of-use for daily quality control requirements.

• Texture analysis of solid samples with fixtures for bending, breaking or squeezing tests
• Universal container holder for measurements in original sample containers
• Electrical temperature module for parallel plates with active upper heater for tests up to 400 °C
• Disposable, parallel plate measuring geometries eliminate timeconsuming cleaning
• Comprehensive pressure cell portfolio for tests up to 600 bar and 300 °C
• Tribology cell based on ball-on-three-plates principle for testing friction, lubrication and wear
• Serrated or sandblasted measuring geometries to eliminate wall slip of complex fluids
• Optional 21 CFR part 11 module for HAAKE RheoWin Software to meet FDA requirements
• Variety of sample covers including solvent trap to minimize solvent evaporation
• Pin or ring rotor for investigation of drying processes
• Large dimension building material cell with exchangeable lamella profiles
• Coaxial cylinders with helical grooves or serration to avoid sedimentation and wall slip