Manufacturing

• Uses smaller material quantities for faster, cost-effective development
• Converts easily from hot melt extrusion (HME) to twin screw granulation (TSG) applications
• Operates at throughput ranges from 20g/h up to 2.5kg/h
• Processing length: L/D ratio 40:1
• Screw elements and barrel design scale geometrically across the all Thermo Scientific Pharma Extruders and allow easy process scale-up
• Easy-to-operate with user-friendly, intuitive touch screen with integrated feeder control
• Maximize lab space with small footprint machine
• Perfect for glove box or isolator applications with removable touch screen
• All material contact parts are easily removable
• Documentation of extrusion parameters and suitable for process analytical technology (PAT)
• GMP-compliant, full validation available: FAT, SAT, IQ/OQ

• 2-in-1 process design – quickly disassemble parts for easy cleaning and process switching from HME to TSG.
• Simple continuous process integration – plug-and-play functionality with upstream and downstream process equipment (e.g., feeders, chill rolls, pelletizers, dryers, etc) simplifies production line design.
• Less optimization time, cost and effort – extruder process parameters are scaleable to larger Thermo Scientific extruders due to geometric similarity with minimal use of expensive ingredients.

The HAAKE PolyLab QC Modular Torque Rheometer Features:
Backward Compatibility

• Compatible with previous model mixers and extruders
• Adapts to existing accessories for use
• Imports previous data for compatibility

• Extrudability of newly developed materials
• Manufacturing homogeneous melts
• Manufacturing films, foils, strands and profiles for optical and mechanical testing as well as outdoor exposure tests
• Measuring rheological behavior (viscosity, elasticity)
• Testing individual and combined influences of additives (stabilizer, lubricant) and functional additives (anti-oxidation, UV-stabilizers, pigments and fillers)
• Foam extrusion

Overcome drug formulation challenges

Pharmaceutical manufacturers are using conical and twin-screw extruders to mix drug molecules with bioactive polymers in situations where drug ingredients are poorly soluble or unstable during processing. Extruders are also useful in preparing enteric dosages, sustained release dosages, in taste-masking, and to create forms such as films.

Gain the advantages of a continuous process

Continuous granulation offers a more efficient and cost-effective route for producing tablets and capsules, particularly when developing new formulations where scale-up is difficult due to the narrow optimal working points found in batch devices such as mixers, agitators and choppers.

• Requires only 3g (4mL) of material for compounding
• Small footprint, fanless design with separate, touch-screen control for operation in fume cabinet or glovebox applications
• Removable and exchangeable product contact parts for quick and easy cleaning
• IP 54 for protection against dust and water allows the Pharma mini HME to be spray-washed
• Useable as small-scale production unit for throughputs of 100g/h
• Touch screen control with user levels and password protection
• Data logging software as option to record temperatures, torque, and screw speed
• Optional batch conversion kit to use the Pharma mini HME as small batch mixer
• Complementary workflow solution when coupled with the Thermo Scientific™ HAAKE™ MiniJet injection molder

Lithography systems can accommodate substrates of arbitrary shapes with lateral dimensions of up to 1400 x 1400 mm²