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Introducing the Thermo Scientific™ Pharma 11 Twin-screw Extruder
Perform material- and labor-effective extrusion with Thermo Scientific™ Pharma 11 Twin-screw Extruder, which requires only a small amount of active pharmaceutical ingredient, operating at throughput levels as low as 20g/h.
Key Features
The Pharma 11 Twin-screw Extruder Features:
Uses smaller material quantities for faster, cost-effective development
Converts easily from hot melt extrusion (HME) to twin screw granulation (TSG) applications
Operates at throughput ranges from 20g/h up to 2.5kg/h
Processing length: L/D ratio 40:1
Screw elements and barrel design scale geometrically across the all Thermo Scientific Pharma Extruders and allow easy process scale-up
Easy-to-operate with user-friendly, intuitive touch screen with integrated feeder control
Maximize lab space with small footprint machine
Perfect for glove box or isolator applications with removable touch screen
All material contact parts are easily removable
Documentation of extrusion parameters and suitable for process analytical technology (PAT)
GMP-compliant, full validation available: FAT, SAT, IQ/OQ
Key Benefits
The parallel 11mm twin screws and compact design of the Pharma 11 Twin-screw Extruder is fully scalable with the Thermo Scientific stand-alone pharmaceutical compounding systems. Together, you can obtain process relevant results or even perform small scale production.
If you need a complete extrusion solution, a wide range of accessories are available for the Pharma 11 Twin-screw Extruder, including volumetric and gravimetric feeders, a conveyor belt and a pelletizer.
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Pharmaceutical manufacturers are using conical and twin-screw extruders to mix drug molecules with bioactive polymers in situations where drug ingredients are poorly soluble or unstable during processing. Extruders are also useful in preparing enteric dosages, sustained release dosages, in taste-masking, and to create forms such as films.
Horizontally split barrel (up to 40:1 L/D) is hinged for easy access to the screws; simple screw removal device promotes quick and easy cleaning and configuration changes
Barrel is constructed in segmented modules that can be reconfigured to suit a variety of polymer processes
Replaceable barrel liners can be made from special materials for abrasive or aggressive applications
Barrel segments are available for feeding solids and liquids or for venting
Secondary feeders and vacuum pumps can also be incorporated into the system
Powerful control software is programmed to recognize plug-in ancillaries
Large color touch screen interface incorporates on-screen, real-time trend display
Testing individual and combined influences of additives (stabilizer, lubricant) and functional additives (anti-oxidation, UV-stabilizers, pigments and fillers)
