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Introducing the Thermo Scientific Pharma mini HME Micro Compounder
The Thermo Scientific™ Pharma mini HME is a GMP compliant conical micro compounder for Hot Melt Extrusion in research and development in the pharmaceutical industry. When developing new drugs, shortening time-to-market and reducing waste of expensive API’s and overall development costs provide a distinct competitive advantage. Hence, quick and early assessment of new API/excipient formulations is critical. Hot melt extrusion and continuous processing can lead to speedier formulation development and cost efficient production. The Thermo Scientific Pharma mini HME allows users to identify the right drug candidates for hot melt extrusion by compounding as little as three grams of material.
Key Features
With the Pharma mini HME, we offer a micro twin-screw compounder which requires as little as three grams of total material to identify the right drug candidates for hot melt extrusion. The compounder with conical co- or counter-rotating screws is designed to minimize waste and reduce downtime necessary for cleaning.
Requires only 3g (4mL) of material for compounding
Small footprint, fanless design with separate, touch-screen control for operation in fume cabinet or glovebox applications
Removable and exchangeable product contact parts for quick and easy cleaning
IP 54 for protection against dust and water allows the Pharma mini HME to be spray-washed
Useable as small-scale production unit for throughputs of 100g/h
Touch screen control with user levels and password protection
Data logging software as option to record temperatures, torque, and screw speed
Optional batch conversion kit to use the Pharma mini HME as small batch mixer
Complementary workflow solution when coupled with the Thermo Scientific™ HAAKE™ MiniJet injection molder
Key Benefits
Materials:
Pharmaceutical ingredients (API’s)
Excipients
Medical polymers
Drug delivery systems
Soft gels
Applications:
Hot melt extrusion
Medical devices
Implants
Controlled drug release
Handling and processing of highly potent API’s in a glovebox
A small footprint reduces clean room volumes, and lower ingredient consumption reduces handling and operator exposure.
Trust the Experts at Spectra Research Corporation
Spectra Research Corporation (SRC) offers a range of innovative high-quality scientific products and laboratory services to industrial and scientific markets throughout Canada.
Specifications
Motor power
400W
Speed range
10…360 min-1
Max. torque
5 Nm / shaft
Power supply
230V ± 10%, 50/60 Hz
115V ± 10%, 60 Hz
Temperature
max. 280 °C with 2 set points
Heating time
<10 min
Volume
3 g (4 ml)
Screw design
Co- or counter-rotating, pharma
grade stainless steel 1.4112 (440B)
Barrel
High performance / pharma grade
stainless steel M340
Catalog number
Unit Size
Barrel
Description
Max. Screw Speed
Price (CAD)
553-6050
–
High performance / pharma grade stainless steel M340
Pharmaceutical manufacturers are using conical and twin-screw extruders to mix drug molecules with bioactive polymers in situations where drug ingredients are poorly soluble or unstable during processing. Extruders are also useful in preparing enteric dosages, sustained release dosages, in taste-masking, and to create forms such as films.
Horizontally split barrel (up to 40:1 L/D) is hinged for easy access to the screws; simple screw removal device promotes quick and easy cleaning and configuration changes
Barrel is constructed in segmented modules that can be reconfigured to suit a variety of polymer processes
Replaceable barrel liners can be made from special materials for abrasive or aggressive applications
Barrel segments are available for feeding solids and liquids or for venting
Secondary feeders and vacuum pumps can also be incorporated into the system
Powerful control software is programmed to recognize plug-in ancillaries
Large color touch screen interface incorporates on-screen, real-time trend display
