905-890-0555

Thermo Scientific Continuous Granulation

Gain the advantages of a continuous process

Continuous granulation offers a more efficient and cost-effective route for producing tablets and capsules, particularly when developing new formulations where scale-up is difficult due to the narrow optimal working points found in batch devices such as mixers, agitators and choppers.

 

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Description

Pharma 16 Twin-Screw Extruder

Pharma 16 Twin-Screw Extruder

Thermo Scientific DXR 2xi Raman Imaging Microscope

 DXR™2xi Raman Imaging Microscope

 Antaris II FT-NIR Analyzer

Antaris™ II FT-NIR Analyzer

continuous granulationWhy continuous granulation

In pharmaceutical production, individual process steps are traditionally executed in batches. This is true of granulation. Ingredients undergo granulation and agglomeration, while keeping a homogeneous particle size distribution. The changes in physical properties, such as better flow behavior, compressibility, low dust formation and, possibly, optimized release profile of active ingredients, favor the subsequent tableting.

The process can be continuously operated, from mixing of the starting powders to the packaging of the final tablets, by using a twin-screw extruder and subsequent drying in a fluidized bed system.

The benefits of continuous processing are many. It is easier to enclose the whole process using smaller scale equipment that has a small footprint. This process provides greater flexibility in batch sizes as small amount of materials are used, improving control and consistency. Continuous processing eliminates dispensing, reducing risk of operator error in weighing out ingredients and in the handling of ingredients.

Since the entire process is modular, the critical process steps are relatively easily scaled-up and, one can set up facilities for development (approx. 1 kg/h) to the production scale (approx. 300 kg/h).

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Contact Spectra Research

Address

3585 Laird Rd., Unit 15 & 16,
L5L 5Z8 Mississauga
Ontario
Canada

Phone :  905-890-0555

Toll Free : 1-866-753-4433
Fax :  905-890-1959

About Spectra Research

Spectra Research Corporation (SRC) offers a range of innovative high-quality scientific products and laboratory services to industrial and scientific markets throughout Canada.

Established in 1993, SRC is a subsidiary of Allan Crawford Associates (ACA), one of Canada’s largest distributors of electronic components, test equipment and integrated networking solutions.

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