CoVid-19 Pandemic – Service Continuity and Safety Measures

The ACA Group’s Management Team has been closely monitoring the daily developments pertaining to the COVID-19 pandemic and adjusting requirements as guided by the Public Health Agency of Canada and the Canadian Centre for Disease Control.

Our priority throughout this time is ensuring the safety of our staff and their families, while ensuring continued and uninterrupted service to all our customers.

As the events of the COVID-19 outbreak have unfolded, our pandemic plan has been activated and the following measures put in place:

  • Ability to operate without interruption, with work from home capabilities – minimizing service disruptions.
  • Working closely with our supply partners to ensure there will be no interruptions in the supply chain, as well we are continuously communicating with our logistics partners to ensure we are able to honour the delivery schedules committed to our customers.
  • All updates relating to Covid-19 and the effects they may have on our ability to supply products will be communicated to our customers immediately.
  • We are replacing face-to-face meetings with video and phone conferencing through Microsoft Teams or other similar applications.
  • We are postponing all non-essential travel for all employees. We will consult with customers on situations where we need to travel and come on site to finish any physical installations. Training of personal will be done through video conferencing.
  • Implementing self-isolation policies for our staff returning from any international travel, or exposure to anyone they may have come in contact for any reason.
  • Promoting social distancing protocols and procedures in our offices, including asking our clients to refrain from visiting if they are symptomatic or have travelled in the last 14 days.
  • Increasing sanitization measures throughout our offices have been implemented.
  • All trade shows have been cancelled.
  • We are having daily updates to address any questions, concerns or issues employees may have as we go forward with Covid-19 situation.

We are carefully reviewing updates to determine our course of action, and as this is a constantly evolving situation, we will continue to provide coronavirus updates to you via our website www.aca.ca.

Thank you for your patience as we work through this unprecedented time together. Please contact me directly if you wish at brianf@aca.ca or my direct line at 905-502-2081.

ACA Group of Companies

Brian Flippance
CEO/President

The Three Most Critical Insights in Regenerative Medicine

ROKIT Healthcare INVIVO .jpgINSIGHT #1) Traumatic injuries, vascular abnormalities, cancer treatment and malfunctioning organs…traditionally, these involve loss of tissue or organ that could be restored only through surgical transfer from the patient and donor or through the use of synthetic materials. However, common challenges facing surgical care are that there is only so much tissue that can be removed from the same patient to reconstruct a damaged area. Also, the use of human or animal donor tissues have posed inherent risks of infection and graft failure.

 

 

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INSIGHT 2) But perhaps one of healthcare’s most profound problems, especially in the face of a globally aging population, is the sheer shortage of organ donors and rejection in existing transplantation methods. In 2016 in the U.S., around 116,000 were on the waitlist for an organ transplant while less than 10% of that number made up the donors list. Similar figures (respective to population size) are reported from other developed countries as in the EU; in less developed countries, the numbers on the waiting list are grossly masked by the numbers of people who pass away without even making it to the waitlist.

It is true that over the years post-transplantation 5-year survival rates have significantly improved (73% today versus 63% in 1980s for the heart) thanks to advances in immunosuppressive drug development. However, patients subjected to chronic regimens face new risks. From the risks of developing non-adherance to risks of developing antibodies to the biologics, post-allogeneic transplant management has its own concerns that can decrease quality of life and increase healthcare costs.

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INSIGHT 3) There has been a rapidly growing attention to 3D printing in biomedicine in the past 5 years, both as a tool for tissue engineering research but also for clinical applications taking advantage of the unique benefits of personalized, automated printing of cells and biomaterials. The movement of the 3D bioprinting community is toward one vision – to generate organs and tissues on demand according to patients’ needs, using patients’ own cells.

In just a little over a decade since it was introduced to medical application, 3D printing has demonstrated its ability to revolutionize the delivery of health care across the world. Beyond the use in surgical prototyping and planning, 3D printing is being applied in fabricating constructs (medical devices or implants) with required structural, mechanical, and biological complexity that conventional methods lack in reproducing for patients. A 3D-printed bioresorbable airway splint saved a newborn’s life in the U.S.; a patient suffering with a degenerative cervical spine received a 3D-printed spinal implant recapitulating the complex internal architecture; a production of skin grafts clinically proven to treat burns was automatized with a 3D printer in Spain.

ROKIT Healthcare’s 3D printing

CELLINK

The world’s first bioink company

CELLINK was founded in 2016, and in four short years has grown to become a leader in bioprinting—a meteoric rise. CELLINK designs and develops cost-effective bioprinting technologies that enable researchers to 3d print organs and tissue for applications that span a broad range of industries, from pharmaceuticals to cosmetics. Their patent-pending bioink is a biomaterial innovation that allows human cells to grow and thrive as they would in their natural environment.

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                                       Bioprinted intestinal cells

Researchers leverage CELLINK technologies to print liver, cartilage, and skin tissues—demand for which is poised to exponentially grow because of the chronic shortage of transplant organs. CELLINK is helping revolutionize tissue engineering and change the future of medicine as societal expectations about “quality of life” rapidly evolve.

CELLINK bioink, bioprinters and software are now used in more than 700 labs in over 50 countries. CELLINK’S team of mechanical, electronics, robotics and software engineers, as well as UX/UI designers, biomaterial science and tissue engineers, have made it possible for CELLINK to fully develop their bioprinters, bioinks and software in-house. It’s a remarkable success story—many chapters of which have yet to be written.

CELLINK has ongoing collaborations with an impressive list of highly regarded organizations such as MedImmune, MIT, and Takara Bio, and its printers are used for research at Harvard University, Merck, Novartis, the U.S. Army, Toyota, Johnson & Johnson and more. CELLINK keeps good company.

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CELLINK BIO X 3D printer

CELLINK products

CELLINK BIO X 3D BioPrinter

The BIO X is the new go-to 3d bioprinter for life science companies, researchers and innovators who work with bioprinting. It’s the most user friendly bioprinter on the market and a complete standalone product. The BIO X is an ingenious creation on many levels. Judges at RedDot Award 2018 certainly thought so as they made the BIO X a prize winner at this prestigious event—the Oscar Awards of product design

Click here to learn more about the BIO X.

 

 

CELLINK_3.pngINKREDIBLE 3D Bioprinters

The INKREDIBLE and INKREDIBLE+ bioprinters bring streamlined efficiency to every lab—along with superior technical support. The INKREDIBLE bioprinter is a pneumatic-based extrusion bioprinter with dual printheads and a UV LED curing system. It’s a cost-effective unit that enables innovators to enter the 3d bioprinting field and print living tissues with ease.

Robust and reliable, the INKREDIBLE+ is the only true benchtop bioprinter on the market.

Click here to learn more about INKREDIBLE and INKREDIBLE+ bioprinters.

 

CELLINK_4.pngCELLINK bioinks

CELLINK developed the first universal bioink that’s compatible with any cell type in any 3d-bioprinting system. It is now used in labs all over the world. CELLINK continues to design an impressive array of bioinks with superior printability and bioactive properties that guide cellular fate processes.

Request a quote

Click here to request a quote on any CELLINK product.

 

Sensofar Metrology

Sensofar Metrology

Sensofar Metrology is one of two divisions of the Sensofar group, based in Barcelona, Spain, an innovation and technology hub. Sensofar Metrology is renowned for its:

  • High-end, non-contact, 3D surface profilers based on complementary confocal, interferometry, focus variation and spectroscopy reflectometer techniques;
  • Consultancy within the field of metrology;
  • Advanced R&D generating patented technologies contributing to hundreds of surface metrology applications worldwide.

Non-contact 3D surface metrology

3D surface metrology is the measurement and characterization of micro- and nano-scale features on natural or manufactured surfaces. This is done efficiently by capturing the 3D spatial coordinates of points on a surface using a non-destructive optical technique.

Sensofar

 Surface topography at the nanometer level

Optical surface profilers have crucial advantages over tactile approaches:

  • Measurement is non-contact, so there’s no damage to the object being measured;
  • Optical techniques can measure through transparent media, are fast and flexible, and yield 3D (areal) results;
  • Measurement performance depends on wavelength and numerical aperture, eliminating limitations caused by the physical size of a stylus tip.

The most common optical techniques available are confocal, interferometry and focus variation, each of these has their own strengths and weaknesses.

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Superior vertical resolution with confocal

Confocal: Confocal profilers measure the surface height of smooth to very rough surfaces, with spatial sampling as low as 0.10 μm—ideal for critical dimension measurements. High NA (0.95) and high magnification (150X) objectives are available to measure steep local slopes >70° on smooth surfaces with and up to 86° on rough surfaces. Sensofar’s proprietary confocal algorithms provide vertical repeatability on the nm scale.

Interferometry: White-light vertical scanning interferometers (VSI) measure the surface height of smooth to moderately rough surfaces, providing nm vertical resolution regardless of the NA. Sensofar’s new S neox optical 3D profiling microscope can use all available magnifications to profile shape features with no compromise in height resolution.

Focus variation: Focus variation has been developed for measuring the shape of large rough surfaces. Sensofar’s implementation of this approach has been specifically designed to complement confocal measurements at low magnification. Highlights of the technology include high slope surfaces (up to 86°), highest measurement speeds (mm/s) and large vertical range. This combination of features is largely suited to tooling applications.

 

Sensofar Metrology products

New S neox: The new S neox optical 3D profiling microscope outperforms all previous microscopes of its kind in terms of performance, functionality, efficiency and design. It combines all three of the above techniques: confocal (best for surfaces with high slopes), interferometry (highest vertical resolution) and focus variation (measures shape in seconds). The S neox does all this in the same sensor head without any moving parts. The S neox delivers three-in-one technologies for class-leading areal measurement.

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S neox helps in archaeological study of an ancient rock drawing

S neox Five Axis: The S neox Five Axis S measures samples at different positions of rotation and elevation,thereby generating a group of individual measurements. The SensoFIVE software merges all of the surfaces, providing a sample surface with high accuracy by using the stacked image information of each single surface measurement. Merging different elevations, the system can provide shape and form information on sharp edges and/or critical surfaces.

Request a quote

Click here to request a quote on any Sensofar product.

ROKIT Healthcare

ROKIT Healthcare

ROKIT Healthcare is a bioprinting and biotechnology company based in Seoul, South Korea, with research bases in Boston, U.S.A. and Saarland, Germany. Founded in 2012 Rokit was one of the first companies in the world to print PEEK (polyetheretherketone) and other high-performance materials.

In recent years Rokit Healthcare has gone from just selling 3D printers and materials to offering integrated solutions. With a renewed focus on regenerative healthcare, the company provides complete solutions for bioprinting. Rokit Healthcare now offers bioinks, has a tissue bank, a 3D printing service and provides training.

ROKIT

ROKIT Healthcare strives to improve the quality of life and health around the world by addressing the problem of aging and age-related diseases with total, healthcare solutions. 3D biofabrication and the development of patient-specific tissue and organ regeneration therapies are their core capabilities. This explains Rokit’s Healthcare’s bold slogan:

Aging is disease.

From Rokit Healthcare’s perspective, bioprinting sets the base for the personalized therapy solutions they are planning to introduce to global hospitals, from patient-specific skin, cartilage and bone regeneration to heart and retina patch biofabrication solutions. Rokit believes that bioprinting must come together with other preventive medicine and diagnostic technologies, digitalization and healthcare management strategies to be truly effective at the level of patient outcomes. Rokit Healthcare thus seeks to address regenerative medicine and healthcare from a much wider vantage point, with bioprinting as an important but not dominant theme.

ROKIT Healthcare understands that there is a paradigm shift underway in healthcare economics that will usher in new therapeutic methods. They see themselves as a pioneer in this new paradigm that will feature the use of autologous cells, cell sheet technology, and emerging 4D biofabrication technology.

Rokit Healthcare products

Invivo: The Invivo 3D bioprinter improves the efficiency of tissue engineering and regenerative medicine research by allowing the creation of 3D cellular structures by printing scaffolds for hard tissues, as well as using bio-inks for the creation of soft tissue.

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Dr. INVIVO 4D: The world’s first sterile, all-in-one organ regenerator, Dr. INVIVO 4D

was developed for biomedical researchers and material engineers to pattern cells, biomolecules, and polymers to explore multi-material 3D composite structures, from tissues to novel biocompatible materials. 4D biofabricating technology is the best way to recapitulate the complex and functional human body.

Bioinks: Rokit Healthcare bioinks are optimized for human tissue printing through innovation by the finest biomedical researchers and material engineers. Their ideal bioink formulations satisfy material and biological requirements that mimic cellular components found in tissue-specific microenvironments.

EpiTem: EpiTem is a human reconstructed skin model that has disruptive applications in the 4D bioprinting industry.

Request a quote

Click here to request a quote on any Rokit Healthcare products.

ROKIT Healthcare

Introduction email from Shane Graham

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To whom it may concern,

I would like to introduce myself as your new Account Manager, West for Spectra Research Corporation (SRC).

As you know SRC is known for it’s excellent customer service, attention to detail and providing the highest quality products. SRC is committed to you the customer and therefore, the decision was made to expand and create a dedicated role for the West. This will ensure our customers will continue to receive the excellent service that they have grown to expect from SRC.

A little background on me, I have spent the last 23 years in biological science, pharmaceuticals and medical devices. I am very excited to be part of the SRC team and to help meet the needs of all of our valuable customers.

To make sure  that SRC continues to provide high quality solutions, Account Managers such as myself are continually updated and trained on new exciting products and markets. I will be making an effort to see as many of you in person over the next few weeks.  If there is a date/time that works for you, please let me know and I will confirm with you as soon as possible.

Regards,

Shane Graham
Account Manager, West
Spectra Research Corporation
(403) 630-7541

 

SEMINAR TOUR : Nanolithography for 2D and 3D Materials

RC and Heidelberg Instruments are conducting a seminar tour to show the remarkable capabilities of NanoFrazor nanolithography 2D and 3D systems.

* Click on the applicable city name above to register

Based on thermal scanning probe lithography developed at IBM Research, NanoFrazor lithography is the fastest and most versatile of all scanning probe lithography techniques.This new lithography system’s applications include:
  1. High-quality metal contacting of 2D materials
  2. Tuning photonic molecules
  3. Generating nanofluidic devices
  4. Generating spintronic circuits
Register for one of the upcoming seminars to see NanoFrazor lithography in action!
* For more information on the seminar nearest you, please use the linked city names above.

Connect With Us

 

DLS at High Concentration

Dynamic Light Scattering (DLS) is an effective measurement technique used for measuring the hydrodynamic size of common nanomaterials including colloids, nanoparticles, proteins, and polymers. Despite the versatility of this technique, there are several important considerations that cannot be ignored when using light scattering to characterize high-concentration solutions. While it is possible to make measurements on high volume-fraction samples without dilution, it raises additional questions about the meaning of the hydrodynamic size. To understand why this is the case we need to discuss two effects encountered in concentrated solutions: multiple scattering and mutual diffusion.

Download the PDF White Paper to Learn More

 

Workshop : Hybrid Nano-lithography Technology combining Thermal SPM and Direct Laser Lithography

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SwissLitho commercialized tSPL

This fall SwissLitho is releasing its newest product “NanoFrazor Explore DLS“. This unique hybrid nano-micro lithography system, which combines thermal Scanning Probe Lithography (tSPL) with Direct Laser Sublimation (DLS) was developed by Heidelberg Instruments and SwissLitho.

SwissLitho commercialized tSPL out of IBM Research in 2014 and its commercial NanoFrazor systems are installed at various institutions and used for the fabrication of nanodevices when usual nanolithography techniques get complicated or fail.

You are cordially invited to this workshop which aims to introduce the capabilities of the technologies of Heidelberg Instruments and SwissLitho and discuss their opportunities for McGill University researchers.

Date and time: 1:30 pm, Sept 17th, 2019

Place/Room: Rutherford Physics building, RM 105, 3600 University street



Program:
1:30 pm NanoFrazor lithography – an overview
1:55 pm
NanoFrazor DLS – mix&match lithography in the same resist and same system
2:20 pm
Overview on various pattern transfer processes for NanoFrazor lithography
2:45-3:00 pm
Open user discussion
3:00-5:00 pm
Live System demo in CR

SRC logoWe are looking forward to seeing you at our workshop!

For more information please contact : Serge Dandache
Hybrid Nano-lithography

 

lithography Technology

Compounding solutions for 3D filament production

Optimize formulation and production in fewer steps

With the popularity of 3D printing new polymer formulations need to be tested in order to meet the demands of new product applications for industries such as aerospace, medical devices, and automotive. Consequently, polymer compounding for the production of novel 3D filaments becomes a critical step in the workflow for designing successful 3D printing applications.

Advantages of twin-screw extrusion for fused filament fabrication (FFF)

The Thermo Scientific™ Process 11 Twin-screw Extruder and the Thermo Scientific™ HAAKE™ PolyLab OS Rheomex PTW Twin-screw Extruder offer significant benefits over single-screw extruders for 3D filament development to help:

  • Minimize or eliminate the effects of coalescence to maintain particle size distribution
  • Avoid a second heat history when processing heat sensitive polymers
  • Improve layer-to-layer adhesion with uniform binder dispersion
  • Avoid time and energy consumption by eliminating the need to dry hygroscopic materials
  • Reduce waste of expensive additives like pharma excipients, graphene and metals

Thermo Scientific™ Process 11 Lab-scale 3D Filament Production System Process 11 Lab-scale

Use this compact benchtop solution for research-scale formulation and process development. Figure 1 shows this system with:

  • Process 11 Twin-screw Extruder
  • Thermo Scientific™ Process 11 Melt Pump
  • Filament spooler

From 20 g/h up to 2 kg/h throughput, this system is ideal for development of new compounding processes. Easy to operate this system provides process data that supports the scaling up of your 3D filament production process, while reducing the amount of expensive raw material during formulation development

FL53142-3D Filament Systems Promo-EN-FL-53142-FINAL

 

 

Reduce 3D filament development time

Streamline 3D filament development by combining compounding and filament formation in one system. Based on our twin-screw extruders, we have designed two systems that allow you to quickly test different formulations and produce spooled 3D filaments in fewer steps than traditional workflows. Both systems produce filaments directly from the compounding process by using a melt pump for pulsation-free output, which ensures a precise filament diameter and significantly reduces time and labor costs. The thermal stress on the filament material is also reduced by eliminating unnecessary heat-cool cycles that occur if mixing and filament production are separated.

Thermo Scientiἀc™ HAAKE™ PolyLab Pilot-scale 3D Filament Production System

Use this system for lab-to-small scale process development and production. Figure 2 shows this system with:

  • HAAKE PolyLab OS Rheomex PTW Twin-screw Extruder
  • Thermo Scientiἀc™ Melt Pump for the OS Rheomex Extruder
  • Filament spooler on a mobile bench

Reach material throughputs of up to 5 kg/h with this system that includes the ability to characterize new material compounds with mixer tests and capillary rheology.

HAAKE PolyLab