SRC Suppliers Providing Vital Analytical Technology for R&D in the Pharmaceutical Industry

SRC suppliers are at the forefront of many key sectors of the economy, including the pharmaceutical industry. Today we look at technologies provided by WITec, a German company that has established itself as a market leader in the field of nano-analytical microscope systems, as well as by Physical Electronics, the world’s leading supplier of UHV surface analysis instrumentation.

Witec

Combining Confocal Raman Microscopy with techniques such as topographic Raman imaging and Atomic Force Microscopy

Development, production and quality control in the pharmaceutical industry requires efficient and reliable control mechanisms to ensure the safety and the therapeutic effect of the final products. Not surprisingly, these products can vary widely in composition and application, presenting challenges to pharmaceutical researchers. Several properties of pharmaceuticals can be difficult to study with conventional techniques because of their inability to be used to chemically differentiate materials with sufficient spatial resolution and without damage or staining. Therefore, methods of analysis that provide both comprehensive chemical characterization and the flexibility to adjust the method to the investigated specimen are preferred in pharmaceutical research.

Confocal Raman Microscopy

alpha300 R—the benchmark in Raman imaging systems

Confocal Raman Microscopy (CRM) is a well-established and widely used spectroscopic method for investigating the chemical composition of a sample. In pharmaceutical research CRM can be used to:

  • Probe the distribution of components within formulations;
  • Characterize the homogeneity of pharmaceutical samples;
  • Determine the state of drug substances and excipients; and
  • Characterize contaminants and foreign particulates.

The information obtained through the use of CRM is also invaluable for:

  • Drug substance design;
  • Development of solid and liquid formations; and
  • Process analytics and patent infringement and counterfeit analysis.
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Confocal 3D Raman volume image of a pharmaceutical emulsion

In pharmaceutical development it is of great importance to acquire information on drug composition and the distribution of chemical components. With confocal Raman images the distribution of the chemical components in diverse drug systems can be clearly visualized. CRM is a non-destructive method and combining it with other techniques, such as topographic Raman imaging and AFM, expands its analyzing capabilities. Thus, a variety of different pharmaceutical samples can be investigated and the chemical information from Spectral Raman analyses can be linked to topographic data and further surface characteristics. CRM and its correlative analyzing methods contribute to a comprehensive understanding of a pharmaceutical product and facilitate its development.

XPS and TOF-SIMS for the pharmaceutical industr

Surface analysis techniques that analyze the top few atomic layers of materials play an important role in the pharmaceutical industry. From production quality control to understanding surface interactions in biological systems, these analytical techniques are useful at all steps in the life cycle of a pharmaceutical for creating more effective products and processes. Examples where surface analysis can provide benefits include:

  • Contamination identification and qualification
  • Imaging of tablet components-drugs and excipients
  • Surface segregation and coverage
  • Packaging analysis
  • Purity and cleanliness validations
  • Sterilization studies
  • Reverse engineering/patent infringement
nanoTOF II ToF-SIMS instrument

Physical Electronics nanoTOF II ToF-SIMS instrument

X-ray Photoelectron Spectroscopy (XPS) and Time-of-Flight Secondary Ion Mass Spectrometry (TOF-SIMS) are two of the most commonly used surface analysis methods for studying pharmaceutical samples. The techniques are highly reliable and provide chemically specific complementary information:

  • EXP provides quantitative analysis of elemental composition and short-range chemical bonding information. However, it may be difficult to distinguish large molecules that contain the same few primary elements.
  • TOF-SIMS can distinguish molecular-scale components with high sensitivity but requires standards for quantitative analysis.
  • Combined with cluster ion beams for organic profiling, XPS and TOF-SIMS can also provide 2-dimentional and 3-dimensional depth profiles and imaging.

Contact

For more information about WITec and Physical Electronics and the leading technologies they provide to the pharmaceutical industry, please contact us for an enlightening dialog on the topic. Click here to download the flyer

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PHI VersaProbe 4 — Scanning XPS Microscope

SRC 2021

At Physical Electronics, the innovation never stops. And as the sole supplier of PHI products in Canada, SRC can help you leverage PHI innovation to achieve your goals.

For today’s advanced materials

The PHI VersaProbe 4 is a highly versatile, multi-technique instrument with PHI’s patented, monochromatic, micro-focused, scanning X-ray source.  The instrument offers true SEM-like ease of operation with superior micro-area spectroscopy and excellent large-area capabilities. The fully integrated multi-technique platform of the PHI VersaProbe 4 offers an array of optional excitation sources, sputter ion sources, and sample treatment and transfer capabilities.  These features are essential in studying today’s advanced materials and supporting your material characterization.

The new PHI VersaProbe 4 has improved spectroscopic performance, new large area imaging and mapping capabilities, and environmentally friendly modern configuration with efficient power consumption, faster pump-down and ergonomic design.

The PHI VersaProbe 4 offers:

  • Intuitive sample navigation and confident analysis area identification
  • Optimized depth profiling
  • Superior micro-area analysis
  • Suite of specialized solutions for in-situ characterization of advanced materials

PHI—trusted by researchers the world over

Publishing recent discoveries in science and technology in peer-reviewed literature is a critical function of members of the research community. In 2021 over 4500 scholar publications, including peer-reviewed articles and book chapters, were published using PHI XPS instruments. On top of this there were more than 60 papers published in the high-impact journals (Nature and Science group). The new PHI VersaProbe 4 will reinforce the trust that researchers have in PHI instruments.

Contact

To learn more about the new PHI VersaProbe 4 or to request a quote, contact us at SRC. We’d be delighted to put PHI innovation to work for you.

 

 

New Hire Announcement – George Kameka

George Kameka

SRC is pleased to announce the recent hiring of George Kameka as Account Manager for Western Canada covering the provinces of Manitoba, Saskatchewan, Alberta and British Columbia commencing November 23, 2021.

George obtained a B.Sc. in chemistry from Concordia University in Montreal and started his career at Metrohm/Brinkmann Instruments in Mississauga. After two years he accepted the technical sales representative position for Western Canada in Calgary.

George worked for Mettier Toledo for 15 years, the first seven as a sales specialist for electrochemical and weighing products, working out of Calgary and covering Western Canada. The following eight years he worked as advanced instrument sales specialist (thermal analysis, automated reactors and in-situ analysis), covering Ontario and Western Canada.

George also worked for three years for ThermoFisher Scientific as a technical sales representative for the ICP, ICP-MS, GC, GC_MS products, covering Western Canada from Calgary.

George is a technical sales representative with extensive industry experience and expertise in scientific instrumentation and equipment sales in a broad array of industries. He has proven success in developing competitive market strategies for direct and distribution sales and promotes new business through effective presentations and product demonstrations at trade shows and client sites. George builds and maintains relationships with customers by collaborating with them to identify their technical and business needs—SRC is most pleased to welcome him to our team.

Contact

George Kameka
Account Manager, West
Spectra Research Corporation

 

Additive Manufacturing of Ceramics for Biomedical Applications

Additive manufacturing (AM), also known as 3D printing, is a transformative/disruptive approach to industrial production in a broad range of fields that cost-effectively enables the creation of lighter, stronger, and more geometrically complex parts and systems. It is another technological advance made possible by the digitization of processes. AM uses data computer-aided-design (CAD) software or 3D object scanners to direct hardware to deposit material, layer upon layer, in precise geometric shapes. As its name implies, AM adds material to create an object. By contrast, when you create an object by traditional analog methods, it is often necessary to remove material through milling, machining, carving, shaping or other means.

Additive Manufacturing 1

The ability to design and print virtually any object shape using a diverse array of materials, such as metals, polymers, bioinks—and ceramics—has given rise to the use of AM in biomedicine in both research and clinical settings. The world of 3D ceramic printing has come a long way since the 1980s, when it was considered suitable only for the production of functional or aesthetic prototypes, and a more appropriate term for it at the time was “rapid prototyping.” This article reviews the additive manufacturing of ceramics in biomedicine, as well as the technology and products of a leading SRC supplier, 3DCeram.

The additive manufacturing of ceramics for biomedical applications allows for the creation of bone substitutes, custom implants and surgical tools. The exceptional biocompatibility, extremely regular porous structure, capacity for the formation of complex geometrical shapes and mechanical strength are the main qualities of these 3D bioceramics. 3Dbioceramics can also be produced cost-effectively and relatively quickly and, when incorporated into the human body, provide more safety and comfort for the patient and require less follow-up after surgery. Given these many attributes, the future of additive manufacturing of ceramics for biomedical applications is extremely bright and the market is expected to grow by leaps and bounds as healthcare systems seek to control spiralling patient care costs, and applications not previously considered advisable or possible continue to emerge.

3DCeram

 

 

The medical sector has always been interested in cutting-edge technologies, which is why 3DCeram began working with biomedical players in 2005. In subsequent years 3DCeram has focused on developing a mastery of the 3D printing ceramics process, 3D printers, ceramic materials and services encompassing maintenance and training. Today, the company is the undisputed global leader in the additive manufacturing of ceramics for biomedical applications.

3D Ceram leverages stereolithography (SLA) 3D printing technology to manufacture custom-made or small series bone substitutes and cranial or jawbone implants. The technology can be used to produce ceramic components layer by layer using a laser that polymerizes a paste composed of photosensitive resin and ceramic. The parts are then subjected to a heat treatment (debinding followed by sintering) that eliminates the resin and densifies the ceramic.

The medical sector

Custom-made HAP implant for the repair of large and complex craniofacial bone defects

With over a decade of medical 3D printing experience under its belt, 3DCeram produces a range of ceramic 3D printers and materials that are suitable for biomedical applications, including the accessible C100 EASY FAB system and the production-grade C3600 ULTIMATE. The company offers a number of materials that have been specifically formulated for biocompatibility and osteointegration, such as HAP (Hyd roxyapatite), TCP (Tricalcium Phosphate) and ATZ (Alumina Toughened Zirconia). 3DCeram’s products are suitable for many types of biomedical applications, from cranial and jawbone implants to dental devices.

C3600 ULTIMATE

Ceramaker 3600 ULTIMATE

In the biomedical sector, however, the ability to 3D print highly advanced or customized devices is not quite enough: all medical parts and products must undergo and meet stringent requirements. When it comes to the adoption of ceramic 3D printing in the medical sphere, certifications have not been a deal breaker, but they have created a bottleneck. CDCeram has pursued streamlining of the certification process for its biomedical customers through a new partnership with Gregory Nolens.

With a PhD in Biomedical Sciences and expertise in additive manufacturing and medical regulations, Gregory Nolens is uniquely equipped to help biomedical companies and players to not only implement ceramic 3D printing for medical device development and production, but to obtain the necessary certifications.

Contact

SRC is proud to represent 3DCeram in Canada and make available to our Canadian customers in the biomedical field the full range of 3DCeram products. Click here to contact SRC to learn more.

 

 

SRC Suppliers Making Extraordinary Advances in the Biopharmaceutical Sector

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Biopharmaceuticals are large and complex molecular drugs that are mainly obtained from proteins and nucleic acids of living organisms, such as microorganisms and animal cells, also known as transgenic organisms. These drugs are obtained using biotechnology and have high-therapeutic value. Biopharmaceuticals are also known as biologics and biotech drugs and are usually administered by intravenous, subcutaneous, or intramuscular injections and are more efficient than the conventional small molecule drugs.

Biopharmaceuticals are an alternative to previously less effective and sometimes unsafe treatments and offer several benefits. Biopharmaceutical benefits include their highly effective and potent action, reduced side effects, capacity to be tailored according to the specific medical requirements of patients and potential to actually cure diseases at the root level. Biopharmaceuticals have reduced the number of deaths due to cancer and HIV/AIDS in the past decade and have changed the treatment of several chronic diseases, such as diabetes and cardiovascular diseases.

Some of the biopharmaceuticals include monoclonal antibodies, erythropoietin, growth hormones, recombinant proteins, recombinant human insulin, purified proteins, interferon, and vaccines. Recombinant human insulin was amongst the first substances to be approved for therapeutic purposes. Currently, there are nearly 300 biopharmaceutical products that have been approved and are available in the market.


Sphere Fluidics

 

Sphere Fluidics is a SRC supplier focused on developing technology that enables leading-edge research and accelerates biopharmaceutical discovery. They do this by providing novel single cell analysis systems for the rapid screening and characterisation of single cells. Their patented picodroplet technology is specifically designed to increase the likelihood of finding that rare molecule or cell that can lead to a life-changing medicine. 

Sphere Fluidics has made a fast-track antibody discovery: a high-throughput method for identifying and isolating rare cells secreting antigen-specific antibodies. Antibody-derived biologics have become a major class of modern medicine, particularly in the fight against cancer and autoimmune diseases. Highly efficacious immunoglobulin-based drugs have been developed naturally via the antibody-producing B cells of the mammalian immune system, although finding rare cells with the right characteristics has always been challenging.

The Cyto-Mine® Single Cell Analysis System is Sphere Fluidics’ flagship product—the first integrated, benchtop system to automatically analyse, sort and dispense millions of individual cells in just a single day. Cyto-Mine® technology finds and isolates cells secreting antigen-specific antibodies from complex cell populations.

 

 

Biolin Scientific webinars/seminars annoucement

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Wettability and Adhesion of Real Surfaces Seminar

Join us for a 1 hour seminar about Wettability and Adhesion, where we will go through how to utilize contact angles for wettability measurements and evaluation of adhesion. We will also address the theory behind them and emphasize strategies how to apply these measurements to real, non-ideal surfaces which may be heterogeneous in both surface chemistry and surface roughness. 

Wettability and adhesion are key parameters in numerous industries such as coatings, biotechnology and electronics. The seminar will include lecture and a demonstration of how to account for the surface roughness and wettability determination for advanced research.

You can also download our White Paper on Surface roughness and wettability.

November 30, 2021
Wettability and Adhesion of Real Surfaces Webinar

Virtual Webinar at 10 am (via Zoom)
In-Person Workshop at 2 pm

Decermber 2, 2021
Wettability and Adhesion of Real Surfaces Webinar

Virtual Webinar at 10 am (via Zoom)

 

Decermber 2, 2021
Wettability and Adhesion of Real Surfaces Seminar (In-Person) & Workshop

University of Calgary Main Campus,
Engineering B Building, Room ENB 112
Seminar at 2 pm
Workshop at 3 pm (optional)

 

Biolin Scientific Attension Online Seminar 2021

Scientific Seminar

In collaboration with Biolin Scientific AB, we warmly welcome you to take part in the upcoming Biolin Scientific Attension Online Seminar 2021, Practical applications on surface tension & contact angle. The seminar will be hosted in two sessions on the 30th of November 2021 & participation is 100% free! Sign up today to hear what the subject matter experts have to say about their latest research.

Check out some of our guest speakers!

Iria Torres
Researcher
Sanofi – Frankfurt

Katja Klinar
Researcher at University of Ljubljana,
Slovenia

Jakub Sandak

Jakub Sandak
Researcher at
InnoRenew CoE & University of Primorska

Andrew White

Andrew White
Scientist
at BASF Agricultural Solutions

Timo Kotilahti

Timo Kotilahti
Research
engineer in Aalto University

Dr. Ankit D.Kanthe

Dr. Ankit D.Kanthe
Analytical Scientist at
Bristol Myers Squibb

Morning session

Time Presentation Speaker and title
09:00 – 09:10 am Welcome/Introduction  Biolin Scientific
09:10 – 09:30 am Surface tension evaluation of small volume samples through the pendant drop method Iria Torres Teran, Sanofi
09:30 – 09:50 am Surface tension measurements of METNINTM lignin fractions Petri Ihalainen, Metgen
09:50 – 10:10 am Using Theta Flex for bioproducts research at Aalto University Timo Kotilahti, Aalto University
10:10 – 10:30 am TBD
10:30 – 11:00 am Improve Accuracy and Repeatability of Contact Angle Measurements with the Theta Flow    Susanna Laurén, Biolin Scientific
11:00 – 11:15 am  Break
11:15 – 11:35 am Assessing surface properties of heterogeneous and porous biological origin building materials, such as wood Jakub Sandak, Innorenew
11:35 – 11:55 am Optimizing characterization of wetting behaviour of milk powders by contact angle measurements Riitta Partanen, Valio
11:55 – 12:15 pm Wettability in gluing and finishing processes of lignocellulosic materials Tomasz Krystofiak, Poznań University of Life Sciences
12:15 – 12:45 pm Importance of goniometry study in membrane science Joanna Kujawa, Nicolaus Copernicus University
12:45 – 1:30 pm Q&A

All times are in CET (Central European Time)

Biolin Scientific Attension Online Seminar 2021

Research Corporation Your Partner in Battery Research and Development

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Battery Research and Development

THE SUSTAINABLE GLOBAL ECONOMY RUNS ON BATTERIES 

Advances in battery technologies are at the forefront of a sustainable global economy, and refinements that further reduce the cost and optimize the performance of batteries are essential. SRC, through our technology partner suppliers, provides laboratories pursuing these refinements with pivotal technologies for battery R&D and QA/QC. Please keep reading to learn more about instrumentation from SRC and our innovative suppliers.

THERMO SCIENTIFIC INSTRUMENTS

Thermo Scientific

Thermo Scientific helps innovate in dry or low-solvent electrode manufacturing. The twin-screw extruder compounds
anode material with minimized solvent addition. The highly viscous pastes are processed into pellets which are easily
transported and stored without aging. The pellets can later be coated onto collector foil and calendared in one step.

To learn more, click here to download the Continuous-twin-screw-compounding-in-a-confined-space
Cost-efficient-and-ecologically-twin-screw-compounding

OXFORD INSTRUMENTS

OXFORD INSTRUMENTS

Electrolytes are a key component in battery performance. Oxford Instruments’ benchtop NMR technology can quickly and easily distinguish between the diffusion behavior of different electrolyte solvents and help characterize important parameters such as conductivity and ion transference. For battery R&D, the Oxford Instruments X-Pulse Broadband Benchtop NMR Spectrometer provides critical data for electrolyte design.

To learn more, click here to download the X-Pulse Application Note 20

PHYSICAL ELECTRONICS

PHYSICAL ELECTRONICS

X-ray Photoelectron Spectroscopy (XPS) from Physical Electronics (PHI) is an important tool for
battery material research and development. XPS can provide insights into battery performance at realistic operating conditions, and help determine the precise location of interfaces between battery components. Electronic band structure of organic and inorganic materials can also be characterized using XPS.

To learn more, click here to download the PHI XPS Battery Characterization Application Note.

NANOSURF

NANOSURF

The Flex AFM Atomic Force Microscope from Nanosurf can be used to characterize the surface topography of battery materials and components. The AFM tip can also be made electrically active and
used as a probe for nanoscale conductive/ resistive pathways. Measurements can be done within an
electrochemical cell to passively observe changes due to charge/discharge events.

To learn more, click here to download the Nanosurf Flex AFM Brochure

WITEC

WITEC

Raman Imaging Systems from WITec provide comprehensive battery material characterization.
Raman imaging can highlight the distribution of electrolyte and electrode materials and investigate
their crystallinity.

To learn more, click here to download the WITec Alpha300 R Brochure.

BROOKHAVEN INSTRUMENTS

BROOKHAVEN INSTRUMENTS-2

Battery particle charge (zeta potential) can affect slurry production and stability. The Brookhaven
Instruments NanoBrook Omni provides fast, routine measurement of submicron particle size and zeta
potential. This technology will help you understand sedimentation and agglomeration.

To learn more, click here to download the NanoBrook Omni Brochure

AMBIVALUE

Battery AMBIVALUE

AmbiValue’s EyeTech™ Particle Size and Shape Analyzer provides fast and accurate particle size and
shape analysis. Particle morphology is key for achieving optimal battery performance because particle shape affects slurry rheology, electrode coating density, porosity and uniformity.

To learn more, click here to download the EyeTech Brochure

 

Biolin Scientific

Lithium-ion batteries are the main energy storage technology for mobile devices such as smartphones and laptops. The wettability of different parts of Li-ion batteries has become one of the key issues both in terms of manufacturing as well as for the performance and safety of batteries.

To learn more, click here to download the Biolin Scientific wettability-in-li-ion-batteries

Research Corporation Your Partner in Battery Research and Development

Biolin Scientific Attension Seminar 2021

Attension Seminar 2021

Welcome to our Attension Seminar-30th of November, 2021!

We are happy to invite you to an exciting seminar online where researchers from both academy and industry come together to share their insight and experience in practical applications for surface tension and contact angle. Have a look at the agenda for our two sessions below and sign up today!

Morning session

Time Presentation Speaker and title
09:00 – 09:10 am Welcome/Introduction  Biolin Scientific
09:10 – 09:30 am Surface tension evaluation of small volume samples through the pendant drop method Iria Torres Teran, Sanofi

 

09:30 – 09:50 am Surface tension measurements of METNINTM lignin fractions Petri Ihalainen, Metgen
09:50 – 10:10 am Using Theta Flex for bioproducts research at Aalto University Timo Kotilahti, Aalto University
10:10 – 10:30 am TBD
10:30 – 11:00 am Improve Accuracy and Repeatability of Contact Angle Measurements with the Theta Flow    Susanna Laurén, Biolin Scientific
11:00 – 11:15 am  Break
11:15 – 11:35 am Assessing surface properties of heterogeneous and porous biological origin building materials, such as wood Jakub Sandak, Innorenew
11:35 – 11:55 am Optimizing characterization of wetting behaviour of milk powders by contact angle measurements Riitta Partanen, Valio
11:55 – 12:15 pm Wettability in gluing and finishing processes of lignocellulosic materials Tomasz Krystofiak, Poznań University of Life Sciences
12:15 – 12:45 pm Importance of goniometry study in membrane science Joanna Kujawa, Nicolaus Copernicus University
12:45 – 1:30 pm Q&A

All times are in CET (Central European Time)

Evening session