Sphere Fluidics

Sphere Fluidics aims to develop technology that enables leading-edge research and accelerates biopharmaceutical discovery. We do this by providing novel single-cell analysis systems for the rapid screening and characterisation of single cells. Our patented picodroplet technology is specifically designed to increase chances of finding that rare molecule or cell that can lead to a life-changing medicine.

 

Sphere Fluidics | SRC

 

Founded in 2010, Sphere Fluidics is an established Life Sciences company, originally spun out from the University of Cambridge. We initially developed 25 patented products – biochips and specialist chemicals – which currently assist hundreds of customers globally with their research.

Started by producing novel biochip systems and providing R&D services, we have now extended our expertise and are developing a technology platform that enables discovery in a range of growing markets through single cell analysis. Our systems make the development of new biopharmaceuticals faster and more cost-effective, improve monoclonal antibody screening, cell line development, and overall research efficiency in a number of other applications including synthetic biology, single cell diagnostics, prognostics and single cell genome editing.

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  • Cyto-Mine® – Antibody discovery and cell line development workflows streamlined like never before

    • Targeted Discovery – .Rapidly identify and isolate your rare cells of interest.
    • Monoclonality Assurance – Extensive proof of monoclonality for cell line development.
    • Significantly Reduce Timelines and Costs – Tens of millions of cells in pools or hundreds of thousands individually are screened in a single day.
    • Flexibility – Flexible assay design allows quantitative measurement of antibody secretion.
    • Sterility – The entire process is automated, sterile and Animal Origin Free. The Benchtop system is compatible for use in Class II biosafety cabinets.

     

  • Cyto-Mine® – Antibody discovery and cell line development workflows streamlined like never before

    • Targeted Discovery – .Rapidly identify and isolate your rare cells of interest.
    • Monoclonality Assurance – Extensive proof of monoclonality for cell line development.
    • Significantly Reduce Timelines and Costs – Tens of millions of cells in pools or hundreds of thousands individually are screened in a single day.
    • Flexibility – Flexible assay design allows quantitative measurement of antibody secretion.
    • Sterility – The entire process is automated, sterile and Animal Origin Free. The Benchtop system is compatible for use in Class II biosafety cabinets.

     

    • Semi-automated – Modular system for analysis of single cells or biomolecules in picodroplets.
    • High-throughput – High-speed processing, detection and sorting of picodroplets (up to 12,000 per minute).
    • Measure secreted proteins – Enables sensitive detection of secreted proteins (e.g. cytokines, antibodies, enzymes).
    • Choice of parameters – User-defined microfluidic flow rates, picodroplet size, gating settings.
    • Multiple detection modes – Range of optical detection methods (fluorescence, luminescence & scatter).

     

    • Optimized for use with Pico-Surf™ and our other specialist chemicals
    • Compatible with our range of Pico-Gen™ microfluidic biochips.
    • Especially formulated to be biocompatible and stable.
    • High purity and long shelf life (up to one year).
    • Animal Origin Free.
    • Experienced scientific and application support available.
    • Volume – 100 ml, 250 ml, 500 ml

     

  • Pico-Break™ is used to used to gently reduce the stability of picodroplets in order to release cellular or molecular contents into an aqueous medium for subsequent processing.

    Volume 10ml, 50ml
    Features 1. Allows gentle breaking of picodroplets (by phase separation via chemically-induced coalescence).
    2. Compatible with picodroplets stabilised by Pico-Surf™ surfactants.
    3. Contains a dye to visually confirm recovery of sample material.

     

  • Pico-Glide™ is a coating agent designed for users who manufacture their own microfluidic biochips using plasma etched glass or PDMS.

    Volume 5ml, 10ml, 25ml
    Features 1. A specialised chemical solution to promote consistent in-house manufacture of microfluidic biochips.
    2. Minimises non-specific binding interactions.
    3. Improves picodroplet performance and stability.

     

  • – A reliable, high-performing surfactant for droplet microfluidics

    • Biocompatibility– designed for generating aqueous picodroplets in oil
    • Highest droplet stability– shown by assessment of picodroplet fusion, interfacial tension and critical micelle concentration
    • Stability at high temperature– demonstrated by the low level of picodroplet fusion
    • Low voltage for droplet sorting– purity and quality of the surfactants enables a more efficient sorting process
    • Excellent batch-to-batch reproducibility– all products undergo rigorous QC and QA testing to ensure batch consistency
    • Unique and patented molecular surfactant structure – patent freedom to operate in a wide range of application areas.
    • Specialist expertise and support– our team brings extensive experience and support to guide your applications

     


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