Discount Products: Look through products available for a 25% – 50% discount in 2020. The items provided on a first come, first serve basis. View Discounted Products
The first integrated device to automatically perform selective screening, cell isolation and clone verification in a single compact system.
Cyto-Mine® is a high-throughput instrument which uses picodroplet technology and microfluidics to process up to 40 million heterogeneous mammalian cells (in pools) in less than a day. Cells are encapsulated in picodroplets containing growth media, which act as a bioreactor to compartmentalise cells and let them grow, eventually trapping secreted molecules such as antibodies. The unique workflow enables selective screening of single cells to find rare lead candidates. Although principally designed for antibody discovery and cell line development, the flexibility of the platform makes it suitable for a variety of application areas.
When single cells are compartmentalised in individual picodroplets, monoclonality is ensured and you can perform novel assays to determine protein secretion rates, titre and antigen-specificity. Capturing single cells in picodroplets also ensures gentle processing throughout the workflow.
Each run takes place on a disposable Cyto-Cartridge® whichgives you confidence of sterility and minimises crossover risks. Automation of the system reduces human resource requirements and the simple ‘load-and-go’ format makes it easy to use by everyone in the lab. Cyto-Mine®, Cyto-Cartridge® and our specialist chemicals and bioreagents are all Animal Origin Free and GLP-compliant.
Key Features
The next generation single cell analysis system for antibody discovery and cell line development.
Current processes for finding novel antibody targets or developing stable cell lines are time consuming and inefficient. Whether you are screening whole B cell repertoires, hybridomas, CHO or other cells, approaches such as cell sorting, clone picking or limiting dilutions have their associated drawbacks – some do not allow cell secretion assays, some tend to be harsh on the individual cells impacting cell viability and outgrowth. Existing approaches are suboptimal, costly, require various individual steps, therefore potentially introducing human error and contamination.
Cyto-Mine® is the new generation solution which allows you to accelerate, automate and simplify your antibody discovery and cell line development workflows.
Targeted Discovery. Rapidly identify and isolate your rare cells of interest.
Monoclonality Assurance. Extensive proof of monoclonality for cell line development.
Significantly Reduce Timelines and Costs. Tens of millions of cells in pools or hundreds of thousands individually are screened in a single day.
Flexibility. Flexible assay design allows quantitative measurement of antibody secretion.
Sterility. The entire process is automated, sterile and Animal Origin Free. The Benchtop system is compatible for use in Class II biosafety cabinets.
Key Benefits
Flexible Assay Design for Antibody Screening
Cyto-Mine® technology enables rapid, miniaturised assays of target protein secreted from encapsulated cells. Assay format can be tailored to suit your needs. From IgG secretion assays for productivity screens to antigen-specific assays for B cell mining or hybridoma fusion screens or customised assays to assess functionality, post-translational modifications or reporter assays, there is a solution for you.
Evidence of Monoclonality
There is an ever-increasing need for proof of monoclonality in single cell analysis. Cyto-Mine® ensures single cell status in a number of ways. Initially, cells are encapsulated into picodroplets at high dilution so that probability of 2 or more cells per picodroplet is incredibly low (about 0.1%). Uniquely, visual proof of monoclonality is provided by ultra-high speed, multi-frame optical imaging immediately prior to dispensing.
Single Cell Assays
Cyto-Mine® picodroplet technology provides a powerful new way to screen vast quantities of cells for secreted proteins. The combination of the picodroplet approach and flexible assay set up means that the platform can be set up to suit your needs – whether you are working in antibody discovery, cell line development, synthetic biology, or other fields – the platform is very flexible and we would be happy to discuss your experimental needs further with you to see how we can help you reach your goals.
Trust the Experts at Spectra Research Corporation
Spectra Research Corporation (SRC) offers a range of innovative high-quality scientific products and laboratory services to industrial and scientific markets throughout Canada.
Specifications
SYSTEM SPECIFICATIONS
Weight
85 kg (187 lbs) – Boxed 110 kg (242 lbs)
Dimensions
860 mm x 566 mm x 463 mm (34 x 23 x 19 inches (w x h x d))
Voltage [frequency]
100 V (min) to 240 V (max) [@ 50 Hz / 60 Hz] 500W (max)
RUN SPECIFICATIONS
Sample input method
Loaded into single-use disposable Cyto-Cartridge®
Sample input format
Mammalian cells in cell culture medium
Workflows (operation modes)
Monoclonality Assurance; Direct Assay; Cell Line Stability
Destination plate capacity
Plate-by-plate or stacker option (available upon enquiry)
The Energy 11 Twin-Screw Extruder can be set up for a wide range of applications encountered in current battery R&D. The fully ported, horizontally split barrel allows for flexible feeding of solid and liquid ingredients. Interchangeable die designs adapt to a range of materials from dry granules, polymeric solid-state electrolytes, and electrode films to wet slurries. Eight precisely controlled temperature zones along the barrel ensure flexibility in processing.
The DriveAFM, Nanosurf‘s new flagship instrument, utilizes the latest technology to deliver stable, high-end performance. It was designed to fulfill the needs of top notch research, today and in the future.
CleanDrive: stable excitation in air and liquid
Ultra low noise: below 15 fm/√Hz
Direct drive: high-resolution imaging and large scan area
FABRX printers are GMP-ready and CE-marked with stainless steel parts that can be taken apart easily for efficient cleaning. The printheads are exchangeable, meaning you only need one printer for multiple technologies and printheads can be exchanged for cleaning to allow for continuous printing.
GMP Ready
Exchangeable Printheads
Fully Autonomous Printing
Auto Levelling Build Plate
Print Cost Calculation
Multi-Device compatibility
In-Built Camera
In-built Security Measures
Multi-file Type Support
Internal Storage and Management of Multiple Projects
