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Introducing the The NanoFlowSizer inline and real-time measurement in flow
The need for inline particle sizing
Nanotechnology, the design, synthesis, characterization and application of material and devices on the nanometre scale, is revolutionizing many technology and industry sectors: vaccines, medicine, energy, food, inks…
Physical, chemical and biological properties at the nanoscale are completely different from properties of bulk matter.
Key Features
Restrictions in nanoparticle analysis:
Low control over the production process
Interruption of the production flow every time conditions are changed
Need for laboratory analysis
Impossibility to carry out Continuous Manufacturing (24-hour)
Long time for analysis (10 min – hours)
Variations in product quality due to absence of full process control
Reduction in analysis time >90%
Better process understanding promoting innovation
New possibilities to study particle size dynamics in real time
Reduction of production time with 1-3 days per batch
Significant reduction in batch rejection saving € 0.2- 2M per manufacturing eve
Current limitations
Batch rejection
Interruption of production process
No continuous manufacturing
Long time for analysis
Limited performance
Low control over production process
Lead to: Economic losses due to lack of solutions!
Key Benefits
A unique nanoparticle sizer: the NanoFlowSizer
The importance of particle size monitoring
The capacity of nanoparticles to carry out their function is dependent on their size as well as size distribution, which are directly related to efficacy and safety (for patients in pharma applications).
Since the behavior of particles at the nanoscale depends highly on these properties, their control is paramount to the entire development and manufacturing process of nanoparticle products.
Uncompromised monitoring
Pharma industry demands complete control over production processes of their high-quality products that need to comply with stringent regulations and demands, which costs $1 million/day1. They thus require sophisticated, highly efficient Process Analytic Technologies (PAT).
However, there is a lack of such PAT solutions for monitoring particle size and size distribution in the nanoscale regime, hindering nanoparticle applications from reaching full potential.
Trust the Experts at Spectra Research Corporation
Spectra Research Corporation (SRC) offers a range of innovative high-quality scientific products and laboratory services to industrial and scientific markets throughout Canada.
Specifications
Nanoparticles and their applications
Nanoparticles are natural and synthetic particles with a size in the 10-9 m range (1-1,000 nm). Due to their small size they have a large surface area in relation to their volume, conferring them special properties.
Nanoparticles are present in many of the items in our everyday life, such as transparent sunscreens or scratchproof glasses. Of special interest for the pharmaceutical industry, nanoparticles are used under different formulations, such as engineered drug delivery systems targeted to disease cells, reducing damage to healthy ones.
How this analyzer is different
NanoFlowSizer (NFS) is a new non-invasive nanoparticle size analyzer developed by InProcess-LSP, the only one capable of carrying particle size and size distribution measurement for non-solid products inline, at the production flow, with no need to extract or treat a sample.
Results every 10 sec
With the NanoFlowSizer, nanoparticle sizing takes place within 10s, enabling continuous real-time in flow analysis.
The NanoFlowSizer is a new innovative system for continuous, real-time nanoparticle size characterization of colloidal systems, nanosuspensions, nanoemulsions and other dispersed nanoproducts directly in manufacturing processes (inline) or in a laboratory setting (offline).
With the use of the Eyecon2 – Direct Imaging Particle Analyzer, clients may better comprehend particle size and shape variation, which allows them to ascertain why a process is failing, why yield is decreasing, the cause of product variation, and if or how a process should be scaled up for commercial manufacture.
Eyecon2 has reduced cycle time and increased yields due to its use of Fluidised Bed Coating (e.g. Wurster), fluidised bed Granulation/Drying, Twin Screw Granulation, Dry Granamination/Roller Compaction, Extrusion Spheronisation, Milling, Blending, and product transfer process equipment. It uses direct imaging processed in real-time, with ellipses fitted to each particle’s boundary, shape and size reported back, highlighting variations. Continuous monitoring of processes critical quality attributes (CQAs) can be used to devise a data-driven control strategy, and non-product contact is used to ensure proper measurements every time.
