You can create better starch compounds by controlling extrusion conditions for food products. This webinar explains how to improve the quality of your final food product by managing the influence of twin-screw extrusion on various product properties. Webinar Extrusion Conditions Influence Properties Starch Compounds
Background: Starch is a base material for many food products: snacks, cereals, pet food, etc. Yet the gelation process is complex and shaped by many different variables. Processing starch with twin-screw extrusion offers a great flexibility in process design and the opportunity to positively influence products derived from it.
Benefits: Learn how to manipulate processing variables to design a starch matrix that delivers the texture, stability and processability you want. The webinar covers how to choose extruder parameters such as screw set-up, processing temperature and liquid-to-solid ratio to create the desired final food properties. Then see how oscillatory rheometry can deliver the precise analysis needed to ensure a high-quality end product.
Presented by WITec GmbH, this webinar will show the workflow and power of confocal Raman imaging for analyzing the chemical composition, crystallinity, stress, optoelectronic and structural properties of materials and organisms. It will introduce you to state-of-the-art developments in confocal Raman imaging, including:
• Automation for more user-friendliness
• Recording surface topography of rough and uneven surfaces using WITec’s TrueSurface technology
• Improved analysis by simplifying the extraction of information from the data set
WITec confocal Raman microscope.
A live data evaluation of measured datasets will demonstrate the power of confocal Raman imaging today.
Presenter Thomas Dieing, Ph.D., is director of applications and support at WITec GmbH in Ulm, Germany. Dieing obtained his Ph.D. from La Trobe University in Melbourne, Australia in 2005, where he investigated the MBE growth of nitrogen containing III/V semiconductors. In 2006 he joined WITec’s application team and became director of applications and support in 2007.
Technical innovations in Raman microscopy now allow for extremely sharp 2D and 3D Raman imaging. Equipping a Raman microscope with additional techniques such as Atomic Force Microscopy makes correlative Raman microscopy easier by linking chemical with structural information. Attend this free webinar to experience advances in correlative, confocal Raman imaging that make the microscopic procedure and evaluation of data easier and quicker than ever before.
Who should attend: Both new and experienced Raman users, including scientists and researchers from material sciences, life sciences, pharma and other fields that use Raman microscopy.About WITec GMbH: Since its founding in 1997, WITecGMbH has established itself as a market leader in the field of nano-analytical microscope systems (Raman, AFM, SNOM). All WITec products are developed and produced at the WITec headquarters in Ulm, Germany, which enables the most stringent quality control and high quality standards.
WITec, the inventor of topographic Raman imaging, will present at Pittcon 2017 in Chicago the next generation of its patented TrueSurface optical profilometer. The combination of surface analysis and Raman spectral acquisition enables topographic Raman imaging on rough and uneven samples. Onepass simultaneous operation makes 3D Raman chemical characterization easier and faster than ever before. WITec-TrueSurface-Original Topographic Raman Imaging System Redefined
“WITec established Raman topographic imaging with TrueSurface. We then continued to innovate, leveraging the inherent strengths of our systems,” says Dr. Olaf Hollricher, Managing Director of R&D at WITec. “The overwhelmingly positive feedback from our customers confirms that chemical 3D surface analysis with TrueSurface is a successful concept with an enthusiastic following in academia and industry.” WITec-TrueSurface-Original Topographic Raman Imaging System Redefined
With the TrueSurface option, Raman spectra are acquired from precisely along a surface, or at a set, user-defined distance from a surface. This makes the distribution of chemical components within the sample visible in three dimensions. Rough, inclined or irregularly-shaped samples can be investigated with the same ease as standard samples. The requirements of sample preparation can therefore be drastically reduced. WITec-TrueSurface-Original Topographic Raman Imaging System Redefined
As the TrueSurface sensor actively monitors and maintains a set distance between the objective and sample surface, its closed-loop operation can compensate for any variations during measurements with long integration times. This keeps the measurement area in focus at all times and produces sharp chemical Raman images with sub-micrometer resolution. WITec-TrueSurface-Original Topographic Raman Imaging System Redefined
Investigations on pharmaceutical tablet coatings, geological samples, composite emulsions, complex semiconductor structures and many other applications can benefit from the ease of use, accelerated workflow and methodological advantages provided by the new TrueSurface. WITec-TrueSurface-Original Topographic Raman Imaging System Redefined
“TrueSurface is for everybody who wants to just take a sample, as it is, and put it under a microscope for chemical analysis,” explains Dr. Joachim Koenen, Managing Director at WITec. “Also, the combination of confocal Raman imaging and optical profilometry provides additional information on the chemical distribution of the sample components that are of great benefit to our customers.” WITec-TrueSurface-Original Topographic Raman Imaging System Redefined
The new TrueSurface from WITec will be presented at the Pittcon 2017 Conference & Expo at McCormick Place in Chicago, Illinois from March 5th to the 9th. Topographic Raman imaging can be experienced live at booth #1638.
The topographic Raman image of a pharmaceutical tablet shows the distribution of chemical components along a curved surface.
WITec is a leading German manufacturer of confocal and scanning-probe microscopes for state-ofthe-art Raman, Atomic Force Microscopy (AFM), Scanning Near-Field Optical Microscopy (SNOM) and developed the integrated Raman Imaging and Scanning Electron (RISE) microscopy. WITec’s headquarters is located in Ulm, Germany, where all WITec products are developed and produced. Branch offices in USA, Japan, Singapore, China and Spain ensure a worldwide sales and support network. WITec has been distinguished by its innovative product portfolio and a microscope design that enables combinations of the various imaging techniques within one system. An exemplar of the company’s breakthrough development is the world’s first integrated Raman-AFM microscope. To this day, WITec’s confocal microscopes are unrivaled in sensitivity, resolution and imaging capabilities. Significant innovation awards such as the Achema Innovation Award 2015 for the fully automated apyron microscope and a Prism Award 2015 for RISE microscopy document WITec’s enduring success and innovative strength.
Harald Fischer Marketing Director Harald.Fischer@witec.de
Food Rheology – What to do before you press ‘start’
Mouthfeel… Spreadability… Appearance… Stability for shelf-life… Testing the structure of a food is essential to ensure the final product appeals to consumers. The results need to be reliable and food samples are sensitive.
Key rheological results can be thrown off by some easy slip-ups in sample handling or the test method itself. This live webinar reviews the critical steps before pressing ‘start’ on your rheometer:
Design of test method
Dr. Klaus Oldoerp, Sr. Applications Specialist,
Material Characterization, Thermo Fisher Scientific
Gain confidence in your sampling skills, test method, and rheological results from R&D to QC. Register now ›
Addressing challenges in pharmaceuticals where API solubility and processing stability, taste-masking, enterics, and specialized dosage forms are critical projects, Thermo Scientific™ extruders and related analytical instrumentation provide the shortest path from feasibility studies to production in drug formulation and manufacturing. Pharma Hot Melt Extrusion-Drug Formulation-Manufacturing
Compounding and extrusion technologies have been used in manufacturing for centuries and have become a valuable tool in creating novel drug formulations, and in the transition from inefficient batch processing to continuous manufacturing.
creating novel drug formulations, and in the transition from inefficient batch processing to continuous manufacturing.
Featured drug formulation and manufacturing technologies
Melt extrusion has been used in the plastics and polymers industry for decades. Advances in formulation enable poorly soluble drug molecules to be incorporated into solid dispersions using a polymeric carrier. Hot melt extrusion is an alternative to wet agglomeration, a good carrier for sustained release forms and taste-masked dosages. Extrusion processes can also create films for oral strips or dermal patches in a solvent-free process.
According to the US FDA, the continuous manufacturing process reduces human errors caused by starts and stops during the batch process. Continuous granulation is also safer and more reliable. In a continuous process, ingredients are fed and mixtures sent to downstream production. Extruders have been used in wet granulation processes for many years; twin-screw extruders are now playing a central role in pharmaceutical manufacturing. Thermo Scientific Drug Formulation Manufacturing
Rheometry and spectroscopy play important roles in developing and implementing extruder-centered drug formulations. The use of near infrared (NIR) spectroscopy for the analysis of active ingredients in pharmaceutical formulations is well known. The technique is nondestructive, has excellent signal-to-noise ratios and can use fiber optics to take sampling to the process. NIR spectroscopy is an ideal choice to monitor the output of a hot melt extruder. Complementary to NIR in bulk and in-line sampling, Raman spectroscopy adds microscopic imaging to analyze tablet homogeneity and the analysis of co-extrusions.
Hot Melt Extrusion: A Continuous Process for Pharmaceutical Production
Pharmaceutical manufacturers are using conical and twin-screw extruders to mix drug molecules with bioactive polymers in situations where drug ingredients are poorly soluble or unstable during processing. Extruders are also useful in preparing enteric dosages, sustained release dosages, in taste-masking, and to create forms such as films.
Pharma Hot Melt Extrusion-Drug Formulation-Manufacturing
TORONTO – Jan. 18, 2017 –Spectra Research — Tornado Spectral Systems, a leading manufacturer of dispersive optical Raman spectrometers, today announced a new webinar titled, “High Throughput Virtual Slit™ (HTVS™) Impact on Raman Spectroscopy Limit of Detection (LoD) Performance.” The webinar will take placeThursday, February 2, 2017, at 10:00 AM EST / 7:00 AM PST. Tornado Spectral Systems Webinar HTVS Impact-Raman Spectroscopy
Raman spectroscopy is a highly-selective and non-destructive optical measurement technique which relies on the inelastic scattering of laser light to probe molecular structure. Join Tornado’s Senior Instrumentation & Applications Specialist, Jeremy Linoski, in a timely webinar as he will present an LoD study and discuss the improved detection limits and corresponding minimum required acquisition times of 4 binary mixtures using Tornado’s HyperFlux™ PRO Plus Raman spectroscopy system.
Webinar attendees will learn how the HyperFlux PRO Plus demonstrates:
– Better sensitivity for lower detection limits
– Faster measurements
– Why it’s more feasible to deploy for real-time applications
To register for the webinar or for additional information, Click Register Here
About Tornado Spectral Systems:
Founded in 2010, Tornado Spectral Systems designs, manufactures, and sells dispersive optical spectrometers primarily for Raman spectroscopy and spectral-domain optical coherence tomography. Tornado’s HyperFlux spectrometers deliver significantly enhanced sensitivity by using a patented high-throughput virtual slit (HTVS) to eliminate the physical slit of a conventional spectrometer and avoid signal losses while maintaining high spectral resolution, allowing for faster measurements, lower detection limits, and reduced laser power operation. To learn more about Tornado, please visit our website: tornado-spectral.com
Tornado Spectral Systems Webinar HTVS Impact-Raman Spectroscopy
Anasys Instruments’ new patented Tapping AFM-IR mode is the most advanced development in nanoscale IR technology, providing the highest spatial resolution for chemical imaging, enabling monolayer measurement sensitivity and extends the applications of nanoIR to a broader range of samples.
By extending Anasys Instruments patented Resonance Enhanced AFM-IR technique to include tapping mode operation, Tapping AFM-IR extends the boundaries of performance for nanoscale IR spectroscopy. Additionally, the combination of Tapping AFM-IR and patented FASTspectra capability provides users with the most advanced, highest performance nanoscale IR spectroscopy capability with direct correlation to FTIR libraries.
Tapping AFM-IRimaging on 5nm biological membrane at 1660 cm-1
IR line profile shows <10nm chemical spatial resolution using Tapping AFM–IR mode
High resolution, high sensitivity
Tapping AFM-IR has patented features that enhance the resolution of measurement to resolve chemical features down to 10nm. For many applications, Tapping AFM-IRis now only limited by the resolution of the probe. Resonance enhanced AFM-IR has continually demonstrated monolayer sensitivity to enable chemical analysis on the thinnest of surface layers.
High speed chemical imaging – 10x
Tapping AFM-IR improves typical chemical imaging speed by 10x without loss of performance, so you can achieve high resolution imaging faster or choose to take more data in the same amount time.
Highest performance spectroscopy and imaging
The combination of Tapping AFM-IR and FASTspectra FASTspectra provide the highest performance available for nanoscale IR Spectroscopy, extending the boundary to make new discoveries. FASTspectra AFM-IR based spectroscopy is simply the most powerful nanoscale IR spectroscopy capability available. It has excellent spectral resolution and high sensitivity, delivering rich detailed spectra that directly correlate to transmission based FTIR.
Tapping AFM-IR addresses a broad range of material types, and extends capabilities into beyond those most suited by contact mode. New research possibilities are now available in a wide range of areas such as life sciences, nanoparticles and soft polymer materials due to its softer measurement approach.
Tapping AFM-IR demonstrates sub 20nm imaging resolution on block co-polymer substrate of PS/PMMA, as shown in cross-section.
High resolution IR Chemical Imaging
Tapping AFM-IR provides high resolution chemical imaging of PS/PMMA co-polymer at 1730cm-1 and 1492cm-1 and combined to show chemical contrast
Tapping AFM-IR imaging solution nanoscale IR spectroscopy
The MicroDamp Series vibration isolators are an affordable and effective solution, optimized to any instrument’s weight and dimension profile. Utilizing a polished aluminum housing and highly damped composite material, the MicroDamp Series provides a cost-effective solution for instruments experiencing broad frequency vibration noise within their lab environment. Herzan MicroDamp Series Vibration
Affordable and efficient vibration isolation
Minimal amplitude within resonant frequency
Compact, modular form factor
Wide range of supported instrument weights
Easy to integrate into existing instrument setups
No air or electricity required
Light-weight and easy to install/use
Precision Inspection Stations
Highly Sensitive Lab Equipment
The MicroDamp series often utilizes three to four isolators within a vibration isolation platform, depending on the supported instrument’s dimension profile and overall weight distribution. When paired with a damped top plate (i.e. granite, aluminum, breadboard, etc.), the MicroDamp Series becomes a complete solution for instruments requiring a stable and reliable vibration isolation platform.
To determine the correct isolator configuration for your instrument, review the MicroDamp models below and locate the model able to sufficiently support the weight of your instrument.
Please note: the values listed below are for individual isolators only. To correctly select the relevant model for your instrument, multiply the minimum/maximum load capacities by three to determine the total minimum/maximum load capacities. Your instrument must fall within this range to receive optimal vibration isolation performance. If your instrument’s weight does not fall within this range, multiply the minimum/maximum load capacities by a larger number (>3) until your instrument falls within range.
For further instruction on the correct configuration for your instrument, contact a Herzan representative and share your instrument’s weight, dimensions, and approximate load distribution. Once that information has been received, a tailored recommendation will be made to ensure your instrument receives maximum vibration isolation performance from a MicroDamp Series platform.