Inline/Online Particle Characterization

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  • With the use of the Eyecon2 – Direct Imaging Particle Analyzer, clients may better comprehend particle size and shape variation, which allows them to ascertain why a process is failing, why yield is decreasing, the cause of product variation, and if or how a process should be scaled up for commercial manufacture.

    Eyecon2 has reduced cycle time and increased yields due to its use of Fluidised Bed Coating (e.g. Wurster), fluidised bed Granulation/Drying, Twin Screw Granulation, Dry Granamination/Roller Compaction, Extrusion Spheronisation, Milling, Blending, and product transfer process equipment. It uses direct imaging processed in real-time, with ellipses fitted to each particle’s boundary, shape and size reported back, highlighting variations. Continuous monitoring of processes critical quality attributes (CQAs) can be used to devise a data-driven control strategy, and non-product contact is used to ensure proper measurements every time.

     

    • Low control over the production process
    • Interruption of the production flow every time conditions are changed
    • Need for laboratory analysis
    • Impossibility to carry out Continuous Manufacturing (24-hour)
    • Long time for analysis (10 min – hours)
    • Variations in product quality due to absence of full process control
    • Reduction in analysis time >90%
    • Better process understanding promoting innovation
    • New possibilities to study particle size dynamics in real time
    • Reduction of production time with 1-3 days per batch
    • Significant reduction in batch rejection saving € 0.2- 2M per manufacturing eve

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