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Brookhaven Instruments NanoBrook Series
Characterizing proteins, nanoparticles, & polymers confronts users with a difficult choice of instrumentation. Brookhaven Instruments makes that choice easier with its highly configurable NanoBrook series of products.
ZETA POTENTIAL
- Zeta potential for the difficult cases
- For proteins, peptides, mAb, RNA and other biological samples
- For zeta potential in organic solvents
- For oily or viscous media
- For high-salt suspensions
- For samples near the I.E.P.
- 1,000 times more sensitive than other techniques
- Disposable cuvettes, no contamination or alignment
- Built in automatic procedures and parameters (SOP)
- Easy to use
Introducing the Brookhaven Instruments NanoBrook Series
The NanoBrook Series is a Configurable Platform for Particle Sizing and Zeta Potential Measurements
The NanoBrook Series size and zeta potential analyzers incorporate all you need for fast, routine, sub-micron measurements of size and zeta potential. Based on the principles of Dynamic Light Scattering (DLS) for particle sizing and distribution, and based on doppler velocimetry (electrophoretic light scattering or ELS) for zeta potential measurement, most measurements only take a minute or two. The instrument also includes Phase Analysis Light Scattering (PALS) measurements for samples with low mobilities.
Key Features
Features at a glance
SIZING
- Rapid and accurate protein & nanoparticle size distributions
- Multimodal & unimodal size distribution software
- ISO 13321 and ISO 22412 compliant results
- Range: < 0.3 nm to 10 µm
- Three measurement angles: 15°, 90°, and 173°
- Ideal for fast, routine sizing applications in research or quality control
- High power 40 mW diode laser
- Dynamic light scattering at 173° and 90°
- Temperature control, -5 °C to 110 °C
- Compact bench top unit, USB connection
- Molecular weight determination (relative and absolute through Debye plot)
ZETA POTENTIAL
- Zeta potential for the difficult cases
- For proteins, peptides, mAb, RNA and other biological samples
- For zeta potential in organic solvents
- For oily or viscous media
- For high-salt suspensions
- For samples near the I.E.P.
- 1,000 times more sensitive than other techniques
- Disposable cuvettes, no contamination or alignment
- Built in automatic procedures and parameters (SOP)
- Easy to use
Key Benefits
The NanoBrook Omni combines all of the most common configurations
With the NanoBrook Omni, measure samples in nearly every possible suspension environment from high salts such as PBS and sea water to organic solvents and aqueous solutions. Particle and protein sizing, with the highest sensitivity, utilize three measurement angles for truly unbiased measurement results.
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Specifications
| Sample Type | Sizing: Globular proteins, nanoparticles, and small polymers as well as most colloidal-sized materials in any non-absorbing liquidZeta Potential: Proteins, nanoparticle, polymer and colloidal-sized materials, suspended in any non-absorbing liquid, with relative permittivity (dielectric constant) > 1.5 and viscosity < 30 cP. |
| Size Range | Sizing: > 0.3 nm to 10 µm diameter, depending on refractive index and concentrationZeta potential: 1 nm to 100 µm, sample dependent |
| Mobility range | 10-11 to 10-7 m2/Vs |
| Zeta potential range | -500 mV to 500 mV, sample dependent |
| Maximum sample conductivity | Sizing: unlimitedZeta potential: 220 mS/cm, covering saline and PBS solutions for proteins, sample dependent |
| Sample Cells | Sizing: 1 to 3 mL disposable plastic, 50 µL disposable, 40 µL quartz flow cell, 10 µL quartz minimumZeta potential: 180 µL, 600 µL, 1250 µL |
| Concentration Range | Sizing: 0.1 ppm to 50 mg/mL, depending on refractive index and concentrationZeta potential: 40% v/v, sample dependent |
| Signal Processing | Sizing: Dynamic Light Scattering, DLSZeta potential: Electrophoretic & true Phase Analysis Light Scattering, ELS & PALS |
| Correlator | Brookhaven’s TurboCorr, multitau research grade with 510 hardware channels, covering the equivalent of 1010 linearly-spaced channels, 100% efficiency, real-time operation over the entire delay-time range |
| Precision | Sizing: ± 1% typicalZeta Potential: ± 3% typical |
| Temperature Control | -5 °C to 110 °C, ± 0.1 °C, active control. No external circulator required. |
| Condensation Control | Purge facility using dry air, nitrogen preferred |
| Standard Laser | 40 mW red diode laser, nominal 640 nm wavelength |
| Available Scattering Angles | 15°, 90°, and 173° |
| Data Presentation | Average & width, lognormal fit, and multimodal size distribution standard.Doppler Frequency Shift, electrophoretic mobility, zeta potential using Smoluchowski, Hückel or Henry. |
| Compliance | ISO 13321 and ISO 22412 compliant results |
| Power Requirements | 100/115/220/240 VAC, 50/60 Hz, 150 Watts |
| Dimensions | 23.3 x 42.7 x 48.1 (HWD in cm) |
| Weight | 15 kg |
| Environmental Characterisitics | Temperature 10 °C to 75 °C Humidity 0% to 95%, non-condensing |
| CE Certificate | Class I laser product, EN 60825-1:2001 CDRH |
A policy of continual improvement may lead to specification changes.
Datasheet